Figure 1: The effect of adipose tissue and serum glucose on several metabolic risk factors for breast cancer recurrence. Legend: the figure above illustrates the interplay between weight gain and several metabolic factors associated with breast cancer recurrence. *represents a factor that is known to influence recurrence. IGF-1: insulin-like growth factor 1 receptor, SHBG: sex hormone-binding globulin, TNFα: tumor necrosis factor alpha, IL-6: interleukin 6, RBP4: retinol-binding protein-4, CRP: C-reactive protein, 17β-HD: 17β-hydroxysteroid dehydrogenase.