Review Article

Radiation Therapy for Locally Recurrent Breast Cancer

Table 2

Outcomes of patients treated with repeat breast conserving therapy following in-breast local recurrence.

StudyNumber of patientsMedian followup (months)RT techniqueRepeat RT dose (Gy) ≥ Grade 3 toxicity (%)Local control  (%)Overall survival (%)

Deutsch [15]3951.5EBRT50*NR76.977.9
Hannoun-Levi et al. [18]6950.2Brachytherapy30 or 45–5010.277.491.8
Kraus-Tiefenbacher et al. [17]1526IORT20*010093.3¥
Würschmidt et al. [16]4NRNRNR0NRNR
Chadha et al. [22]1536Brachytherapy30 or 45089
Guix et al. [21]3689Brachytherapy30089.4**96.7**
Kauer-Dorner et al. [20]3957Brachytherapy50.116.79387

NR: not reported, Gy: Gray, RT: radiation therapy, EBRT: external beam radiation therapy, IORT: intraoperative radiation therapy.
*Median, mean, at 5 years, **10-year actuarial, ¥at median followup.