International Journal of Breast Cancer / 2012 / Article / Fig 4

Research Article

Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases

Figure 4

Cytotoxicity of M002 in human and murine tumor cells at 48 h post-infection. Plates of human breast cancer cells MDA-MB-361 (a) or murine mammary carcinoma cells SCK (b), and 4T1 (c) were infected with the indicated viruses at an MOI of 1 (black bars) or 10 (gray bars) PFU/cell. At 48 h post-infection, cell viability was assayed by MTT assay. Shown are the averages of quadruplicate determinations, normalized to uninfected cells and expressed as the proportion viable cells.

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