International Journal of Breast Cancer / 2012 / Article / Tab 1

Research Article

Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases

Table 1

Key features of the human breast cancer cell lines used in this study. Some lines can be classified into more than one subtype. Expression of ER and PR and amplification/overexpression of HER2 are indicated (+).

Cell lineCancer typeMolecular subtypeAge of donorSite of isolationReceptor status References
ERPRHER2

BT-474IDCLuminal A/B60Primary tumor++[1114]
MDA-MB-361ACLuminal A40Brain+++[12, 13, 1517]
MDA-MB-231ACBasal51Pleural effusion[1317]
SK-BR-3ACLuminal B/HER243Pleural effusion+[1214, 18]
ZR-75-1DCLuminal A63Ascites+++[1214, 19]

AC: adenocarcinoma, DC: ductal carcinoma, ER: estrogen receptor, HER2: human epidermal growth factor receptor 2, IDC: invasive ductal carcinoma, and PR: progesterone receptor.

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