PKC𝜶 and ER𝜷 Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients

Table 4

(a) PKCα expression is higher in triple-negative breast cancers compared to other subtypes. (b) Correlation of PKCα expression and triple-negative breast cancer is similar in African American and Caucasian patients.

(a)

Outcome	Median (minimum, maximum)		𝑃 value*
	TNBC (𝑁=45)	All other subtypes (𝑁=153)
PKCα (freq)	3 (0, 4)	2 (0, 4)	0.001^†††
PKCα (int)	2 (0, 4)	1 (0, 4)	0.010^†
PKCα (sum)	5 (0, 8)	4 (0, 8)	0.001^†††

* 𝑃 value based on the Wilcoxon Rank-(sum) test. ^†𝑃 value <0.05; ^††𝑃 value <0.01; ^†††𝑃 value <0.001.

(b)

Race	Outcome	Median (Minimum, maximum)		𝑃 value*
		TNBC (𝑁=45)	All other subtypes (𝑁=153)
AA (𝑁=105)	PKC (freq)	3 (0, 4)	2 (0, 4)	0.019^†
	PKC (int)	2 (0, 4)	1 (0, 4)	0.061
	PKC (sum)	5 (0, 8)	4 (0, 8)	0.014^†
Caucasian (𝑁=93)	PKC (freq)	3 (0, 4)	2 (0, 4)	0.010^††
	PKC (int)	2 (0, 3)	1 (0, 4)	0.087
	PKC (sum)	5 (0, 7)	3 (0, 8)	0.018^†

* 𝑃 value based on the Wilcoxon Rank-(sum) test. ^†𝑃 value <0.05; ^††𝑃 value <0.01.