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International Journal of Breast Cancer
Volume 2012, Article ID 819578, 8 pages
http://dx.doi.org/10.1155/2012/819578
Clinical Study

Antibacterial-Coated Suture in Reducing Surgical Site Infection in Breast Surgery: A Prospective Study

Service de Gynécologie-Obtétrique, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, CancerEst, Université Pierre et Marie Curie-Paris 6 75020 Paris, France

Received 12 August 2012; Revised 11 November 2012; Accepted 13 November 2012

Academic Editor: Ian S. Fentiman

Copyright © 2012 Enora Laas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To reduce the incidence of microbial colonization of suture material, Triclosan- (TC-)coated suture materials have been developed. The aim of this study was to assess the incidence of suture-related complications (SRC) in breast surgery with and without the use of TC-coated sutures. Methods. We performed a study on two consecutive periods: 92 patients underwent breast surgery with conventional sutures (Group 1) and 98 with TC-coated sutures (Group 2). We performed subgroups analyses and developed a model to predict SRC in Group 1 and tested its clinical efficacy in Group 2 using a nomogram-based approach. Results. The SRC rates were 13% in Group 1 and 8% in Group 2. We found that some subgroups may benefit from TC-coated sutures. The discrimination obtained from a logistic regression model developed in Group 1 and based on multifocality, age and axillary lymphadenectomy was 0.88 (95% CI 0.77–0.95) ( ). There was a significant difference in Group 2 between predicted probabilities and observed percentages ( ). The predicted and observed proportions of complications in the high-risk group were 38% and 13%, respectively. Conclusion. This study used individual predictions of SRC and showed that using TC-coated suture may prevent SRC. This was particularly significant in high-risk patients.