Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer

Figure 3

Quantitative immunohistochemical expression of HLA class Ia (-A, -B, and -C), HLA class II (DR and DQ), and HLA class Ib (HLA-G and HLA-E) in the 52 patients with invasive ductal carcinoma, associated with (a) metastases in axillary lymph nodes. 𝜒² test: HLA class Ia (𝑃=0.2830; 𝑃>0.05); HLA-II DR (𝑃=0.3010; 𝑃>0.05) and HLA-II DQ (𝑃=0.6894; 𝑃>0.05). HLA-G (𝑃=0.9512) and HLA-E (𝑃=0.3963; 𝑃>0.05), (b) tumor size TS1 (<2 cm), TS2 (2 to 5 cm), TS3 (>5 cm). 𝜒² test: HLA-Ia (𝑃=0.0683; 𝑃<0.05); HLA-DR (𝑃=1.000; 𝑃>0.05); HLA-DQ (𝑃=0.4420; 𝑃>0.05); HLA-G (𝑃=0.5801) and HLA-E (𝑃=0.1826; 𝑃>0.05), (c) histological grade (HG). 𝜒² test: HLA-Ia (𝑃=0.0062; 𝑃<0.05); HLA-DR and HLA-DQ (resp., 𝑃=1.000; 𝑃>0.05); HLA-G (𝑃=0.2695) and HLA-E (𝑃=0.7070; 𝑃>0.05), and (d) nuclear grade (NG). 𝜒² test: HLA-Ia (𝑃=0.0071; 𝑃<0.05); HLA-DR (𝑃=0.5621), HLA-DQ (𝑃=1.000; 𝑃>0.05). HLA-G (𝑃=0.4086) and HLA-E (𝑃=0.0661); 𝑃>0.05.

(a)

(b)

(c)

(d)