Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response

Table 3

Results of analyses using the Cox PH cure model with stepwise variable selection (𝛼=0.05).

Variables	Odds ratio (95% CI)	𝑃 value	Hazard ratio (95% CI)	𝑃 value
HR status		<0.001		0.019
Negative	1		1
Positive	0.30 (0.17, 0.52)		2.83 (1.19, 6.73)
ET therapy		Not selected		<0.001
No			1
Yes			0.05 (0.02, 0.13)
Age		Not selected	0.97 (0.95, 0.99)	0.013
Clinical stage		Not selected		0.007
IIA/IIB/IIIA			1
IIIB/IIIC			1.90 (1.19, 3.03)
Clinical response		0.003		0.004
SD/PD	1		1
PR	0.82 (0.41, 1.65)		0.44 (0.26, 0.74)
CR	2.25 (0.99, 5.07)		0.60 (0.29, 1.25)
HER2 status		0.023		0.019
Negative	1		1
Positive	0.54 (0.31, 0.92)		1.69 (1.09, 2.61)
Histological grade		0.044		0.042
1 and 2	1		1
3	0.59 (0.35, 0.98)		1.58 (1.02, 2.45)
Number of lymph node metastases		<0.001		0.002
0	1		1
1–3	0.43 (0.25, 0.74)		1.15 (0.61, 2.13)
≥4	0.10 (0.05, 0.19)		2.21 (1.25, 3.90)