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International Journal of Breast Cancer
Volume 2013, Article ID 746749, 6 pages
http://dx.doi.org/10.1155/2013/746749
Research Article

Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A

1Department of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And Herzegovina
2Policlinic of Laboratory Diagnostics, Department of Pathology, University Clinical Centre of Tuzla, 75 000 Tuzla, Bosnia And Herzegovina
3Policlinic of Surgery, University Clinical Centre Tuzla, 75 000 Tuzla, Bosnia And Herzegovina

Received 28 July 2013; Accepted 14 November 2013

Academic Editor: Ian S. Fentiman

Copyright © 2013 Nahida Srabovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

VEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression, lymph node status, tumour size, histological grade, and hormone receptor status. To examine the VEGFR-1 and VEGF expressions in tumour and surrounding tissue of 51 breast cancer patients, and in healthy breast tissue of 30 benign breast diseases patients, we used three-step immunohistochemical staining. VEGFR-1 and VEGF expressions were significantly increased in breast cancer tumour in relation to surrounding tissue ( ), and the VEGF expression was significantly increased in lymph node positive breast cancer patients ( ). VEGFR-1 and VEGF expressions were significantly higher in breast cancer tumour compared with healthy breast tissue ( ). Significant correlation between VEGF and VEGFR-1 expressions was found ( ). No significant correlations between VEGF and VEGFR-1 expressions and tumour size, histological grade, and hormone receptor status were found. Increased expression of VEGFR-1 and VEGF in breast cancer tumour and significant correlation between these proteins suggest the possible role of VEGF/VEGFR-1 signalization in breast cancer development, although VEGFR-1 potential prognostic value was not confirmed.