Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial

Table 2

Incidence of postoperative cognitive dysfunction (POCD) for melatonin versus placebo.

Variable	Placebo; 14 (12.75–14) days after surgery	Melatonin; 13 (11–15) days after surgery		Placebo; 84 (80–86) days after surgery	Melatonin; 85 (83–91) days after surgery
POCD (yes/no)	0/20	0/26	1.00	1/15	0/26	0.38
	0%	0%		6.3%	0%

Calculations based on normative data from 133 females aged 40–60 years [30].
value: Fisher’s test.
Neuropsychological testing in median (IQR) days after surgery.
Values are number of patients, percentages, and 95% confidence intervals.