Healthcare Resource Use and Expenditures among Metastatic Breast Cancer Patients Treated with HER2-Targeted Agents

Table 5

Unadjusted healthcare costs during follow-up.

	No treatment	No HER2-targeted agents	HER2-targeted agents
	= 2,590	= 12,840	= 2,629
	Mean (SD)	Mean (SD)	Mean (SD)
All-cause monthly  expenditures
Inpatient	$6,683 (27,528)	$3,416 (13,754)	$3,327 (14,132)^a
Outpatient visits and services	$4,524 (7,794)	$5,910 (7,031)	$9,939 (8,453)^a
Emergency department (ED) visits	$96 (426)	$95 (657)	$119 (1,150)
Outpatient office visits	$220 (703)	$220 (335)	$254 (387)^b
Radiation treatment^d	$427 (1,815)	$588 (1,805)	$734 (1,646)^a
Diagnostic radiology^d	$1,414 (4,073)	$1,083 (2,592)	$1,462 (2,630)^a
Laboratory services	$309 (1,136)	$263 (660)	$287 (567)^b
Other outpatient care^e	$2,058 (4,397)	$3,661 (5,024)	$7,083 (6,640)^a
Prescription fills	$286 (681)	$502 (736)	$839 (1,298)^a
Total healthcare	$11,493 (29,357)	$9,828 (16,182)	$14,105 (16,865) ^a
Breast cancer  monthly  expenditures
Inpatient	$1,525 (13,107)	$271 (2,519)	$338 (3,139)^a
Outpatient visits and services	$2,567 (5,952)	$4,021 (5,758)	$7,858 (7,603^a)
Emergency department (ED) visits	$25 (216)	$35 (471)	$58 (1,054)
Outpatient office visits	$134 (642)	$142 (285)	$185 (343)^a
Radiation treatment^d	$221 (1,295)	$387 (1,513)	$472 (1,376)^a
Diagnostic radiology^d	$1,018 (3,502)	$776 (2,225)	$1,114 (2,315)^a
Laboratory services	$267 (1,421)	$208 (552)	$253 (616)^b
Other outpatient care^e	$904 (2,907)	$2,106 (3,657)	$4,177 (4,627)^a
Office-administered antineoplastic agents	$0 (0)	$367 (1,377)	$1,598 (3,418)^a
Outpatient pharmacy antineoplastic agents	$0 (0)	$89 (225)	$390 (867)^a
Total healthcare	$4,092 (14,548)	$4,382 (6,313)	$8,585 (8,285) ^a

value compared with no treatment and no HER2-targeted agents <0.0001.
value compared with no treatment and no HER2-targeted agents <0.01.
^cPatient monthly expenditures were calculated using the following formula: (patient total expenditures/patient total days of follow-up) * 30 days.
^dRadiation treatment and diagnostic radiology encompass all outpatient radiology services during follow-up.
^eOther outpatient care includes all remaining outpatient services that are not reported individually.