Healthcare Resource Use and Expenditures among Metastatic Breast Cancer Patients Treated with HER2-Targeted Agents
Table 6
Unadjusted healthcare costs during follow-up period among HER2-targeted agent users.
HT−
HT+
De novo
Recurrent
AGE 18–44
AGE 45–64
AGE 65+
= 1,272
= 1,357
= 1,654
= 1,801
Mean (SD)
Mean (SD)
Mean (SD)
Mean (SD)
Mean (SD)
Mean (SD)
Mean (SD)
All-cause monthly expenditures
Inpatient admissions
$4,623 (18,646)
$2,111 (7,605)a
$3,129 (13,402)
$3,443 (14,548)
$2,249 (5,461)
$3,914 (16,706)
$1,861 (4,470)b
Outpatient visits and services
$10,493 (8,752)
$9,422 (8,130)b
$11,517 (8,661)
$9,009 (8,190)a
$11,166 (8,494)
$10,334 (8,497)
$7,091 (7,597)a
Emergency department (ED) visits
$138 (766)
$101 (1,418)
$101 (618)
$129 (1,370)
$129 (744)
$118 (1,277)
$113 (869)
Outpatient office visits
$270 (434)
$240 (335)
$287 (491)
$235 (308)b
$260 (214)
$264 (434)
$207 (281)b
Radiation treatmentd
$817 (1,945)
$655 (1,300)c
$765 (1,310)
$715 (1,815)
$870 (1,527)
$751 (1,532)
$531 (2,136)b
Diagnostic radiologyd
$1,501 (2,521)
$1,425 (2,728)
$1,436 (2,486)
$1,477 (2,712)
$1,647 (2,607)
$1,544 (2,699)
$939 (2,271)a
Laboratory services
$311 (657)
$265 (464)c
$301 (446)
$279 (627)
$349 (562)
$305 (612)
$153 (277)a
Other outpatient caree
$7,456 (6,965)
$6,737 (6,301)b
$8,626 (7,190)
$6,174 (6,116)a
$7,911 (6,727)
$7,353 (6,703)
$5,148 (5,907)a
Prescription fills
$818 (1,369)
$858 (1,227)
$577 (845)
$994 (1,481)a
$923 (1,355)
$848 (1,309)
$722 (1,185)
Total healthcare
$15,934 (20,928)
$12,391 (11,591)
a
$15,223 (16,448)
$13,446 (17,078)
b
$14,338 (10,828)
$15,096 (19,091)
$9,674 (8,982)
a
Breast cancer monthly expenditures
Inpatient
$476 (4,374)
$207 (1,054)c
$601 (4,758)
$183 (1,503)b
$246 (1,181)
$400 (3,654)
$159 (1,737)
Outpatient visits and services
$8,258 (7,793)
$7,475 (7,401)b
$9,582 (7,961)
$6,841 (7,195)a
$8,916 (7,912)
$8,201 (7,573)
$5,388 (6,911)a
Emergency department (ED) visits
$50 (431)
$65 (1,407)
$43 (427)
$67 (1,288)
$52 (403)
$64 (1,247)
$36 (363)
Outpatient office visits
$200 (369)
$171 (317)c
$216 (418)
$167 (289)b
$190 (195)
$194 (382)
$144 (269)c
Radiation treatmentd
$524 (1,682)
$423 (1,006)
$568 (1,115)
$416 (1,507)b
$591 (1,295)
$484 (1,245)
$309 (1,879)c
Diagnostic radiologyd
$1,133 (2,136)
$1,095 (2,470)
$1,167 (2,218)
$1,083 (2,370)
$1,282 (2,484)
$1,182 (2,356)
$668 (1,880)a
Laboratory services
$264 (640)
$243 (592)
$281 (578)
$236 (637)
$317 (793)
$264 (593)
$145 (493)b
Other outpatient caree
$4,497 (5,260)
$3,873 (3,919)b
$5,155 (5,200)
$3,601 (4,418)a
$4,690 (4,867)
$4,342 (4,562)
$2,989 (4,483)a
Office-administered antineoplastic agents
$1,590 (3,186)
$1,606 (3,620)
$2,152 (3,555)
$1,272 (3,292)a
$1,794 (3,401)
$1,672 (3,619)
$1,098 (2,346) c
Outpatient pharmacy antineoplastic agents
$369 (890)
$410 (844)
$227 (534)
$487 (1,001)a
$426 (798)
$403 (894)
$303 (804)
Total healthcare
$9,103 (9,000)
$8,092 (7,521)
b
$10,409 (9,334)
$7,510 (7,394)
a
$9,589 (8,103)
$9,004 (8,472)
$5,850 (7,020)
a
value compared to corresponding HER2-targeted agent subgroup(s) <0.0001. value compared to corresponding HER2-targeted agent subgroup(s) <0.01. value compared to corresponding HER2-targeted agent subgroup(s) <0.05.
dRadiation treatment and diagnostic radiology encompass all outpatient radiology services during follow-up.
eOther outpatient care includes all remaining outpatient services that are not reported individually.
fPatient’s monthly expenditures were calculated using the following formula: (patient’s total expenditures/patient’s total days of follow-up) * 30 days.
