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International Journal of Breast Cancer
Volume 2014, Article ID 581706, 10 pages
Research Article

Breast Cancer with Neoductgenesis: Histopathological Criteria and Its Correlation with Mammographic and Tumour Features

1Department of Surgical Sciences, Uppsala University, 751 85 Uppsala, Sweden
2Department of Pathology, Örebro University, 701 85 Örebro, Sweden
3Department of Pathology, Falun Central Hospital, 791 82 Falun, Sweden
4Department of Research Oncology, King’s College London, London SE1 9RT, UK
5Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden
6Department of Oncology, Helsinki University Central Hospital, 00029 Helsinki, Finland
7Department of Radiology, Oncology and Radiation Science, Uppsala University, 751 85 Uppsala, Sweden
8Department of Surgery, Falun Central Hospital, 791 82 Falun, Sweden
9Department of Surgery, Uppsala Academic Hospital, 751 85 Uppsala, Sweden

Received 12 May 2014; Accepted 9 September 2014; Published 8 October 2014

Academic Editor: Zsuzsanna Kahán

Copyright © 2014 Wenjing Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Breast cancer with mammographic casting type calcifications, high grade DCIS with an abnormal number of ducts, periductal desmoplastic reaction, lymphocyte infiltration, and tenascin-C (TN-C) overexpression has been proposed to represent a more aggressive form of breast cancer and has been denominated as breast cancer with neoductgenesis. We developed histopathological criteria for neoductgenesis in order to study reproducibility and correlation with other tumour markers. Methods. 74 cases of grades 2 and 3 DCIS, with or without an invasive component, were selected. A combined score of the degree(s) of concentration of ducts, lymphocyte infiltration, and periductal fibrosis was used to classify cases as showing neoductgenesis, or not. Diagnostic reproducibility, correlation with tumour markers, and mammographic features were studied. Results. Twenty-three of 74 cases were diagnosed with neoductgenesis. The kappa value between pathologists showed moderate reproducibility (0.50) (95% CI; 0.41–0.60). Neoductgenesis correlated significantly with malignant type microcalcifications and TN-C expression ( and 0.04) and with ER, PR, and HER2 status ( for all three markers). Conclusions. We developed histological criteria for breast cancer with neoductgenesis. Neoductgenesis, by our applied histopathological definition was related to more aggressive tumour biology and malignant mammographic calcifications.