Table of Contents Author Guidelines Submit a Manuscript
International Journal of Breast Cancer
Volume 2015 (2015), Article ID 539721, 10 pages
http://dx.doi.org/10.1155/2015/539721
Research Article

SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma

1Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
2Comprehensive Cancer Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
3Research Division, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA

Received 12 February 2015; Accepted 26 March 2015

Academic Editor: Ian S. Fentiman

Copyright © 2015 Dongquan Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Desantis, R. Siegel, P. Bandi, and A. Jemal, “Breast cancer statistics, 2011,” CA: Cancer Journal for Clinicians, vol. 61, no. 6, pp. 409–418, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. C. DeSantis, J. Ma, L. Bryan, and A. Jemal, “Breast cancer statistics, 2013,” CA Cancer Journal for Clinicians, vol. 64, no. 1, pp. 52–62, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Ferlay, D. M. Parkin, and E. Steliarova-Foucher, “Estimates of cancer incidence and mortality in Europe in 2008,” European Journal of Cancer, vol. 46, no. 4, pp. 765–781, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Lalloo and D. G. Evans, “Familial breast cancer,” Clinical Genetics, vol. 82, no. 2, pp. 105–114, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Bendre, D. Gaddy, R. W. Nicholas, and L. J. Suva, “Breast cancer metastasis to bone: it is not all about PTHrP,” Clinical Orthopaedics and Related Research, no. 415, pp. S39–S45, 2003. View at Google Scholar · View at Scopus
  6. A. J. Redig and S. S. McAllister, “Breast cancer as a systemic disease: a view of metastasis,” Journal of Internal Medicine, vol. 274, pp. 113–126, 2013. View at Google Scholar
  7. O. J. Scully, B.-H. Bay, G. Yip, and Y. Yu, “Breast cancer metastasis,” Cancer Genomics & Proteomics, vol. 9, no. 5, pp. 311–320, 2012. View at Google Scholar · View at Scopus
  8. S. Byler, S. Goldgar, S. Heerboth et al., “Genetic and epigenetic aspects of breast cancer progression and therapy,” Anticancer Research, vol. 34, no. 3, pp. 1071–1077, 2014. View at Google Scholar · View at Scopus
  9. M. A. Blanco and Y. Kang, “Signaling pathways in breast cancer metastasis—novel insights from functional genomics,” Breast Cancer Research, vol. 13, no. 2, p. 206, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Izrailit and M. Reedijk, “Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications,” Cancer Letters, vol. 317, no. 2, pp. 115–126, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. R. J. Pasterkamp, “Getting neural circuits into shape with semaphorins,” Nature Reviews Neuroscience, vol. 13, no. 9, pp. 605–618, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. B. P. O'Connor, S.-Y. Eun, Z. Ye et al., “Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 35, pp. 13015–13020, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. J. R. Leslie, F. Imai, K. Fukuhara et al., “Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation,” Development, vol. 138, no. 18, pp. 4085–4095, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Tamagnone, “Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer,” Cancer Cell, vol. 22, no. 2, pp. 145–152, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Rehman and L. Tamagnone, “Semaphorins in cancer: biological mechanisms and therapeutic approaches,” Seminars in Cell & Developmental Biology, vol. 24, no. 3, pp. 179–189, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Gu and E. Giraudo, “The role of semaphorins and their receptors in vascular development and cancer,” Experimental Cell Research, vol. 319, no. 9, pp. 1306–1316, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. G. C. Harburg and L. Hinck, “Navigating breast cancer: axon guidance molecules as breast cancer tumor suppressors and oncogenes,” Journal of Mammary Gland Biology and Neoplasia, vol. 16, no. 3, pp. 257–270, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. U. Yazdani and J. R. Terman, “The semaphorins,” Genome Biology, vol. 7, no. 3, article 211, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. T. S. Tran, A. L. Kolodkin, and R. Bharadwaj, “Semaphorin regulation of cellular morphology,” Annual Review of Cell and Developmental Biology, vol. 23, pp. 263–292, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Casazza, P. Fazzari, and L. Tamagnone, “Semaphorin signals in cell adhesion and cell migration: functional role and molecular mechanisms,” Advances in Experimental Medicine and Biology, vol. 600, pp. 90–108, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. R. P. Kruger, J. Aurandt, and K.-L. Guan, “Semaphorins command cells to move,” Nature Reviews Molecular Cell Biology, vol. 6, no. 10, pp. 789–800, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Gherardi, C. A. Love, R. M. Esnouf, and E. Y. Jones, “The sema domain,” Current Opinion in Structural Biology, vol. 14, no. 6, pp. 669–678, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Tamagnone and P. M. Comoglio, “To move or not to move? Semaphorin signalling in cell migration,” EMBO Reports, vol. 5, no. 4, pp. 356–361, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Ahmed and B. J. Eickholt, “Intracellular kinases in semaphorin signaling,” Advances in Experimental Medicine and Biology, vol. 600, pp. 24–37, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Toyofuku and H. Kikutani, “Semaphorin signaling during cardiac development,” Advances in Experimental Medicine and Biology, vol. 600, pp. 109–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Toyofuku, H. Zhang, A. Kumanogoh et al., “Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2,” Genes and Development, vol. 18, no. 4, pp. 435–447, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Toyofuku, H. Zhang, A. Kumanogoh et al., “Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling,” Nature Cell Biology, vol. 6, no. 12, pp. 1204–1211, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. R. L. Matsuoka, L. O. Sun, K.-I. Katayama, Y. Yoshida, and A. L. Kolodkin, “Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development,” PLoS ONE, vol. 8, no. 4, Article ID e63207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Kimura, M. Taniguchi, Y. Mikami et al., “Identification and characterization of zebrafish semaphorin 6D,” Biochemical and Biophysical Research Communications, vol. 363, no. 3, pp. 762–768, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Catalano, R. Lazzarini, S. D. Nuzzo, S. Orciari, and A. Procopio, “The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells,” Cancer Research, vol. 69, no. 4, pp. 1485–1493, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Majumder, M. P. Sowden, S. A. Gerber et al., “G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 2, pp. 419–426, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. H.-Y. Li, X.-Y. Cui, W. Wu et al., “Pyk2 and Src mediate signaling to CCL18-induced breast cancer metastasis,” Journal of Cellular Biochemistry, vol. 115, no. 3, pp. 596–603, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. S.-H. Chan, W.-C. Huang, J.-W. Chang et al., “MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis,” Oncogene, vol. 33, pp. 4496–4507, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. W. Wei, Z.-J. Chen, K.-S. Zhang et al., “The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo,” Cell Death & Disease, vol. 5, Article ID e1428, 2014. View at Publisher · View at Google Scholar
  35. J.-M. Renoir, V. Marsaud, and G. Lazennec, “Estrogen receptor signaling as a target for novel breast cancer therapeutics,” Biochemical Pharmacology, vol. 85, no. 4, pp. 449–465, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. N. Dey, B. R. Smith, and B. Leyland-Jones, “Targeting basal-like breast cancers,” Current Drug Targets, vol. 13, no. 12, pp. 1510–1524, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. J.-M. Renoir, “Estradiol receptors in breast cancer cells: associated co-factors as targets for new therapeutic approaches,” Steroids, vol. 77, no. 12, pp. 1249–1261, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Läubli and L. Borsig, “Selectins promote tumor metastasis,” Seminars in Cancer Biology, vol. 20, no. 3, pp. 169–177, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Tamagnone, S. Artigiani, H. Chen et al., “Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates,” Cell, vol. 99, no. 1, pp. 71–80, 1999. View at Google Scholar
  40. M. Yamamoto, K. Suzuki, T. Okuno et al., “Plexin-A4 negatively regulates T lymphocyte responses,” International Immunology, vol. 20, no. 3, pp. 413–420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Yang, T. Li, C. Gao et al., “FOXO1 3′UTR functions as a ceRNA in repressing the metastases of breast cancer cells via regulating miRNA activity,” FEBS Letters, vol. 588, no. 17, pp. 3218–3224, 2014. View at Publisher · View at Google Scholar
  42. X. Wang, C. Lin, X. Zhao et al., “Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor,” Molecular Cancer, vol. 13, article 106, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. X. Feng, Z. Wu, Y. Wu et al., “Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells,” Molecular and Cellular Biology, vol. 31, no. 16, pp. 3457–3471, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. D. V. Skarra, D. J. Arriola, C. A. Benson, and V. G. Thackray, “Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes,” Molecular Endocrinology, vol. 27, no. 11, pp. 1825–1839, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. O. Mendes, H.-T. Kim, and G. Stoica, “Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model,” Clinical and Experimental Metastasis, vol. 22, no. 3, pp. 237–246, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. K. C. Nannuru, M. Futakuchi, M. L. Varney, T. M. Vincent, E. G. Marcusson, and R. K. Singh, “Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-β signaling at the tumor-bone interface,” Cancer Research, vol. 70, no. 9, pp. 3494–3504, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. H. E. Barker, J. Chang, T. R. Cox et al., “LOXL2-mediated matrix remodeling in metastasis and mammary gland involution,” Cancer Research, vol. 71, no. 5, pp. 1561–1572, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. N. K. Nickerson, K. S. Mohammad, J. L. Gilmore et al., “Decreased autocrine EGFR signaling in metastatic breast cancer cells inhibits tumor growth in bone and mammary fat pad,” PLoS ONE, vol. 7, no. 1, Article ID e30255, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. L. Bakiri, S. Macho-Maschler, I. Custic et al., “Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression,” Cell Death & Differentiation, vol. 22, pp. 336–350, 2015. View at Publisher · View at Google Scholar
  50. A. Henke, O. C. Grace, G. R. Ashley et al., “Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer,” PLoS ONE, vol. 7, Article ID e42516, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. J. W. Lee, J. Lee, and E. Y. Moon, “HeLa human cervical cancer cell migration is inhibited by treatment with dibutyryl-cAMP,” Anticancer Research, vol. 34, no. 7, pp. 3447–3455, 2014. View at Google Scholar
  52. S. D. Kim, Y. J. Lee, J. S. Baik et al., “Baicalein inhibits agonist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via cAMP-mediated VASP phosphorylation along with impaired MAPKs and PI3K-Akt activation,” Biochemical Pharmacology, vol. 92, no. 2, pp. 251–265, 2014. View at Publisher · View at Google Scholar
  53. S. Tao, H. He, Q. Chen, and W. Yue, “GPER mediated estradiol reduces miR-148a to promote HLA-G expression in breast cancer,” Biochemical and Biophysical Research Communications, vol. 451, no. 1, pp. 74–78, 2014. View at Publisher · View at Google Scholar
  54. C. Strell, K. Lang, B. Niggemann, K. S. Zaenker, and F. Entschladen, “Surface molecules regulating rolling and adhesion to endothelium of neutrophil granulocytes and MDA-MB-468 breast carcinoma cells and their interaction,” Cellular and Molecular Life Sciences, vol. 64, no. 24, pp. 3306–3316, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. I. A. Mayer, V. G. Abramson, B. D. Lehmann, and J. A. Pietenpol, “New strategies for triple-negative breast cancer—deciphering the heterogeneity,” Clinical Cancer Research, vol. 20, no. 4, pp. 782–790, 2014. View at Publisher · View at Google Scholar · View at Scopus