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International Journal of Breast Cancer
Volume 2015, Article ID 612042, 7 pages
Research Article

Risk Factors for Premenopausal Breast Cancer in Bangladesh

1Women’s College Research Institute, Women’s College Hospital, Toronto, ON, Canada M5G 1N8
2Dhaka Medical College Hospital, Dhaka 1000, Bangladesh
3Amader Gram Breast Care Program, Khulna 9000, Bangladesh
4Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh
5Faculty of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada M5T 3M7
6Anowara Medical Services, Dhaka 1000, Bangladesh

Received 20 March 2015; Accepted 17 June 2015

Academic Editor: Mireille Broeders

Copyright © 2015 Javaid Iqbal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The incidence of premenopausal breast cancer is rising throughout South Asia. Our objective was to determine the role of risk factors associated with Westernization for premenopausal breast cancer in Bangladesh. Methods. We conducted a matched case-control study between January 1, 2007, and December 31, 2010, at four hospitals in Bangladesh. Cases were premenopausal women diagnosed with invasive breast cancer. Controls were premenopausal women with no personal history of breast cancer. Logistic regression was used to calculate the odds ratios (OR) for breast cancer. Results. We identified 129 age-matched pairs. The mean age of breast cancer diagnosis was 37.5 years. Each year decrease in the age of menarche significantly increased the risk of breast cancer (OR = 1.67, 95% CI 1.09–2.56, ). The risk was also increased with a current body mass index of ≥25 kg/m2 (OR = 5.24, 95% CI 1.10–24.9, ). Age at first childbirth, parity, and breastfeeding were not significantly associated with premenopausal breast cancer risk (). Conclusions. Age at menarche and adult weight gain were associated with premenopausal breast cancer risk. Other factors associated with Westernization may not be relevant to premenopausal breast cancer risk in Bangladesh.