Beyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer Genes

Figure 4

The structure of BRCA1 p.Trp1837 (shown in magenta with sticks) in the BRCA-BRCT domain (PDB: 1T15 [6]). Nearby hydrophobic amino acids sidechains from residue 1837 are shown as sticks. Bound BACH1 peptide is shown as teal stick.