Beyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer Genes

Table 2

Experimental structures of genes linked to breast cancer.

Gene	Length	PDBs	Coverage (%)
ATM	3056	0	0.0
BARD1	777	5	42.1
BRCA1	1863	27	17.6
BRCA2	3418	2	1.6
BRIP1	1249	3	1.9
CDH1	882	12	26.2
CHEK2	543	38	86.4
MRE11A	708	1	58.1
MUTYH	549	2	77.3
NBN	754	0	0.0
NF1	2839	6	22.1
PALB2	1186	2	29.7
PTEN	403	6	92.8
RAD50	1312	0	0.0
RAD51C	376	0	0.0
RAD51D	328	1	25.3
TP53	393	142	100.0

Gene lengths and coverage are tabulated from the Universal Protein Resource (Uniprot) [4] and the Research Collaboratory for Structural Bioinformatics (RCSB) [5] databases. The list of genes is taken from the BreastNext panel.