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International Journal of Breast Cancer
Volume 2016, Article ID 7164623, 7 pages
Research Article

A Matched Case-Control Study of Risk Factors for Breast Cancer Risk in Vietnam

1Queen’s University, Kingston, ON, Canada
2Lakeridge Health, Oshawa, ON, Canada
3Hospital K, National Cancer Hospital of Vietnam, Hanoi, Vietnam
4Women’s College Research Institute, Women’s College Hospital, Toronto, ON, Canada
5Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

Received 10 August 2016; Revised 11 November 2016; Accepted 20 November 2016

Academic Editor: Debra A. Tonetti

Copyright © 2016 J. Nguyen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Vietnam has a low age-standardized incidence of breast cancer, but the incidence is rising rapidly with economic development. We report data from a matched case-control study of risk factors for breast cancer in the largest cancer hospital in Vietnam. Methods. 492 incident breast cancer cases unselected for family history or age at diagnosis and 1306 control women age 25–75 were recruited from the National Cancer Hospital (BVK), Hanoi. Structured interviews were conducted and pathology data was centrally reported at the National Cancer Hospital of Vietnam, in Hanoi. Results. Our analysis included 294 matched pairs. Mean age at diagnosis was 46.7 years. Lower mean parity, older age at first parity, increasing weight and BMI at age 18, and increasing BMI at diagnosis were positively correlated with breast cancer cases compared to controls. Age at first menarche and duration of breastfeeding were not statistically different between cases and controls. Conclusions. In this study we demonstrate that breast cancer in Vietnam is associated with some but not all of the published risk factors from Western populations. Our data is consistent with other studies of breast cancer in Asian populations.