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International Journal of Breast Cancer
Volume 2017, Article ID 1796145, 5 pages
Research Article

Clinical Characteristics in Patients with Triple Negative Breast Cancer

1Department of Surgery, New York University Langone Medical Center, New York, NY, USA
2School of Medicine, New York University Langone Medical Center, New York, NY, USA
3Drexel University, School of Medicine, Philadelphia, PA, USA

Correspondence should be addressed to Freya Schnabel; gro.cmuyn@lebanhcs.ayerf

Received 15 February 2017; Accepted 16 July 2017; Published 17 August 2017

Academic Editor: Debra A. Tonetti

Copyright © 2017 Janet Yeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. Methods. Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016. Results. Out of a total of 1964 patients, 190 (10%) patients had TNBC. The median age for both TNBC and non-TNBC was 59 years. There was a significantly higher proportion of African American and Asian patients with TNBC () compared to patients with non-TNBC. BRCA1 and BRCA2 were significantly associated with TNBC (, ). A prior history of breast cancer was significantly associated with TNBC (). There was no relationship observed between TNBC and a history of chemoprevention or patients who had a history of AH or LCIS. Conclusions. We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC. In order to develop more effective treatments, better surveillance, and improved prevention strategies, it is necessary to improve our understanding of the population at risk for TNBC.