Research Article

Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort

Table 1

Baseline patient and tumour characteristics in a DCIS cohort diagnosed between 1986 and 2004, by mammographic features ().

Ductal carcinoma in situ Mammographic features value
StellateCircular or oval shapedPowdery calcificationsCrushed stone calcificationsCasting type calcificationsGalactographic findingArchitectural distortionNormal mammography

Numbers at risk ()16472919289152816
Age (mean, years)64.364.252.055.656.555.965.456.40.36
Detection mode
Screening10 (62.5%)27 (57.4%)24 (82.8%)173 (90.1%)82 (92.1%)1 (6.7%)11 (39.3%)3 (20.0%)<0.001
Not screening6 (37.5%)20 (42.6%)5 (17.2%)19 (9.9%)7 (7.9%)14 (93.3%)17 (60.7%)12 (80.0%)
Type of surgery
BCS14 (87.5%)40 (85.1%)25 (86.2%)159 (83.2%)64 (71.9%)9 (60.0%)18 (64.3%)12 (75.0%)0.06
Mastectomy2 (12.5%)7 (14.9%)4 (13.8%)32 (16.8%)25 (28.1%)6 (40.4%)10 (35.7%)4 (25.0%)
Radiotherapy after BCS
Yes4 (28.6%)14 (35.0%)13 (52.0%)73 (45.9%)34 (53.1%)5 (55.6%)6 (33.3%)4 (33.3%)0.42
No10 (71.4%)26 (65.0%)12 (48.0%)86 (54.1%)30 (46.9%)4 (44.4%)12 (66.7%)8 (66.7%)
Nuclear grade
12 (12.5%)9 (19.1%)4 (13.8%)16 (8.3%)3 (3.4%)0 (0%)4 (14.3%)1 (6.2%)<0.001
26 (37.5%)32 (68.1%)14 (48.3%)56 (29.2%)21 (23.6%)12 (80.0%)13 (46.4%)7 (43.8%)
38 (50%)6 (12.8%)11 (37.9%)120 (62.5%)65 (73.0%)3 (20.0%)11 (39.3%)8 (50%)
Neoductgenesis
0–3p14 (93.3%)45 (100%)26 (89.7%)160 (85.6%)82 (92.1%)13 (86.7%)28 (100%)13 (81.2%)0.14
4–6p1 (6.7%)0 (0%)3 (10.3%)27 (14.4%)7 (7.9%)2 (13.3%)0 (0%)3 (18.8%)
ER
≥10%11 (73.3%)37 (88.1%)23 (71.9%)128 (74.4%)41 (52.6%)12 (85.7%)19 (67.9%)8 (53.3%)<0.001
<10%4 (26.7%)5 (11.9%)6 (28.1%)44 (25.6%)37 (47.4%)2 (14.3%)9 (32.1%)7 (46.7%)
PR
≥10%9 (60.0%)29 (67.4%)21 (72.4%)85 (50%)17 (23.3%)8 (61.5%)16 (61.5%)5 (33.3%)<0.001
<10%6 (40.0%)14 (32.6%)8 (27.6%)85 (50%)54 (76.7%)5 (38.5%)10 (38.5%)10 (66.7%)
HER2
positive4 (28.6%)1 (2.4%)24 (85.7%)63 (35.2%)41 (51.9%)3 (20.0%)4 (15.4%)6 (40.0%)0.002
Normal10 (71.4%)41 (97.6%)4 (14.3%)113 (64.8%)38 (48.1%)12 (80.0%)22 (84.6%)9 (60.0%)
Proliferation
High2 (15.4%)10 (27.0%)8 (34.8%)64 (40.3%)25 (36.8%)0 (0%)13 (48.1%)7 (46.7%)0.96
Low11 (84.6%)27 (73.0%)15 (65.2%)95 (59.7%)43 (63.2%)11 (100%)14 (51.9%)8 (53.3%)
Tenascin-C
High2 (28.6%)11 (34.4%)3 (15.0%)46 (36.2%)22 (36.7%)3 (30.0%)12 (52.2%)8 (72.7%)0.01
Low5 (71.4%)21 (65.6%)17 (85.0%)81 (63. 8%)38 (63.3%)7 (70.0%)11 (47.8%)3 (27.3%)

values are calculated for casting type calcification versus all other types of mammographic features together. Breast conserving surgery = BCS.