Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort

Table 4

Cox regression analyses by histopathological features of neoductgenesis in primary DCIS ().

Ductal carcinoma in situ	Histopathological features of neoductgenesis, 0–6 points
	All women ()		Women undergoing breast conserving surgery ()
	0–3 points	4–6 points	0–3 points	4–6 points
Events
IBE (in situ or invasive)
Univariate HR (95% CI)	Reference	1.19 (0.65–2.17)	Reference	1.01 (0.53–1.94)
Adjusted HR (95% CI)	Reference	1.22 (0.67–2.23)	Reference	1.06 (0.55–2.04)
Invasive IBE
Univariate HR (95% CI)	Reference	0.82 (0.29–2.27)	Reference	0.61 (0.19–1.96)
Adjusted HR (95% CI)	Reference	0.85 (0.30–2.35)	Reference	0.64 (0.20–2.08)
In situ IBE
Univariate HR (95% CI)	Reference	1.60 (0.75–3.39)	Reference	1.44 (0.65–3.19)
Adjusted HR (95% CI)	Reference	1.66 (0.78–3.51)	Reference	1.54 (0.69–3.43)
AIE
Univariate HR (95% CI)	Reference	0.74 (0.30–1.85)	Reference	0.47 (0.15–1.49)
Adjusted HR (95% CI)	Reference	0.78 (0.31–1.94)	Reference	0.49 (0.15–1.56)

Adjusted for type of surgery and postoperative radiotherapy. IBE = ipsilateral breast event; AIE = IBE, regional recurrence and generalized disease.