Germline Mutations in BRCA1 and BRCA2 in Breast Cancer Patients with High Genetic Risk in Turkish Population

Table 2

The characteristics of the groups.

Characteristics	n	BRCA1/BRCA2		BRCA1			BRCA2
		Negative	Positive	Negative	Positive	p	Negative	Positive	p
Age [mean (min-max)]		46 (28-82)	43.7 (27-63)	45.7	45.5	0.781	46.0	41.4	0.190
Germline mutation		81 (81%)	19 (19%)	88 (88%)	11 (11%)		91 (91%)	8 (8%)
Family History	21	17 (81%)	4 (19%)	19 (90.5%)	2 (9.5%)	1.000	19 (90.5%)	2 (9. 5%)	1.000
Bilateral breast carcinoma	7	6 (86%)	1 (14%)	7	0	0.351	6 (86%)	1 (14%)	1.000
Breast + ovarian carcinoma	7	4 (67.2%)	3 (42.8%)	5 (71.5%)	2 (28.5%)	0.173	6 (85.8%)	1 (14.2%)	0.456
Triple-negative tumor	33	25 (75.7%)	8 (24.2%)	27 (81.8%)	6 (18.1%)	0.172	31 (93.9%)	2 (6.0%)	0.715
Below 40 years old	41	33 (80.4%)	8 (19.5%)	37 (90.2%)	4 (9.5%)	1.000	37 (90.2%)	4 (9.5%)	0.715
Triple negative + below 40 years old	8	5 (62.5%)	3 (37.5%)	6 (75%)	2 (25%)		7 (87.5%)	1 (12.5%)
ER Positive	60	51 (85%)	9 (15%)	56 (93.3%)	4 (6.6%)	0.316	55 (91.6%)	5 (8.33%)	0.824
ER Negative	39	29 (74.3%)	10 (25%)	32 (82%)	7 (17.9%)		36 (92.3%)	3 (7.6%)
PR Positive	53	45 (84.9%)	8 (15%)	49 (92.4%)	4 (7.5%)	0.526	49 (92.4%)	4 (7.5%)	1.000
PR Negative	46	35 (76%)	11 (23.9%)	39 (84.7%)	7 (15.2%)		42 (91.3%)	4 (8.6%)
HER 2 Positive	10	10 (100%)	0	10 (100%)	0	0.650	10 (100%)	0	1.000
Right Breast	47	36 (76.5%)	11 (23.4%)	39 (82.9%)	8 (17%)	0.262	44 (93.6%)	3 (6.3%)	0.710
Left Breast	45	37 (82.2%)	8 (17.7%)	42 (93.3%)	3 (6.6%)		40 (88.8%)	5 (11.1%)
Invasive Ductal Carcinoma	86	69 (80%)	17 (19%)	75 (87%)	11 (12%)	0.351	80 (93%)	6 (6.9%)	0.245
Invasive Lobular Carcinoma	10	9 (90%)	1 (10%)	10	0	0.596	9 (90%)	1 (10%)	0.583