Prognostic Implications of MALAT1 and BACH1 Expression and Their Correlation with CTCs and Mo-MDSCs in Triple Negative Breast Cancer and Surgical Management Options
Table 3
Relation between MALAT1 and BACH1 expression and basic characteristics of studied TNBC.
Both -ve
Both +ve
One +ve
value
Age\years
OS time\months (range)
21 (7-34)
10 (10-29)
15 (7-33)
6.63
0.04
DFS\months (range)
18 (5-32)
16 (6-27)
12 (5-30)
4.82
0.09
%
Pathological type
IDC
31
93.9
25
83.3
22
88
1.77
0.44
Others
2
6.1
5
16.7
3
12
Grades
I
4
12.1
5
16.7
3
12
5.11
0.28
II
11
33.3
15
50
14
56
III
19
57.6
10
33.3
8
32
Stage
I-II
29
87.9
7
23.3
9
36
29.4
<0.001
III–IV
4
12.1
23
76.7
16
64
Family history
Positive
5
15.2
6
20
1
4.0
3.07
0.22
Menopause
Pre-
27
81.8
21
70
16
64
2.45
0.29
Post
6
18.2
9
30
9
36
Perineural
Yes
17
51.5
14
46.7
10
40
0.76
0.69
LVI
Yes
22
66.7
23
76.7
19
76
0.98
0.61
MALAT-1
High
0
0.0
30
100
7
28
67.3
<0.001
Positive
0
0.0
30
100
6
24
69.1
<0.001
BACH-1
High
0
0.0
30
100
20
80
71.7
<0.001
Positive
0
0.0
30
100
19
76
69.5
<0.001
Outcome
CR
14
42.4
4
13.3
6
24
15.8
0.003
R
16
48.5
10
33.3
10
40
Died
3
9.1
16
53.3
9
36
TNM stage
T
1.8 (0.5–8)
4.75 (2.5-8)
4 (2.5-8)
21.4
<0.001
0-1
29
87.9
10
33.3
11
44
21.4
<0.001
2-3
4
12.1
20
66.7
14
56
0
33
100
25
83.3
20
80
6.92
0.03
1
0
0.0
5
16.7
5
20
NS: value > 0.05 is not significant; S: value < 0.05 is significant; HS: value < 0.001 is high significant.
