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International Journal of Biomedical Imaging
Volume 2006, Article ID 53050, 11 pages
http://dx.doi.org/10.1155/IJBI/2006/53050

Elasto-mammography: Theory, Algorithm, and Phantom Study

1Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, USA
2Department of Radiology, The University of Iowa, Iowa City, IA 52242, USA
3Department of Civil and Environmental Engineering, University of California, Irvine, CA 92697, USA

Received 4 September 2005; Accepted 7 November 2005

Academic Editor: Jie Tian

Copyright © 2006 Z. G. Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new imaging modality framework, called elasto-mammography, is proposed to generate the elastograms of breast tissues based on conventional X-ray mammography. The displacement information is extracted from mammography projections before and after breast compression. Incorporating the displacement measurement, an elastography reconstruction algorithm is specifically developed to estimate the elastic moduli of heterogeneous breast tissues. Case studies with numerical breast phantoms are conducted to demonstrate the capability of the proposed elasto-mammography. Effects of noise with measurement, geometric mismatch, and elastic contrast ratio are evaluated in the numerical simulations. It is shown that the proposed methodology is stable and robust for characterization of the elastic moduli of breast tissues from the projective displacement measurement.