The First Bioluminescence Tomography System for Simultaneous Acquisition of Multiview and Multispectral Data

Wang, Ge; Shen, Haiou; Durairaj, Kumar; Qian, Xin; Cong, Wenxiang

doi:https://doi.org/10.1155/IJBI/2006/58601

International Journal of Biomedical Imaging

On this page

Abstract References Copyright Related Articles

Open Access

Volume 2006 | Article ID 058601 | https://doi.org/10.1155/IJBI/2006/58601

The First Bioluminescence Tomography System for Simultaneous Acquisition of Multiview and Multispectral Data

Ge Wang,¹Haiou Shen,¹Kumar Durairaj,¹Xin Qian,¹and Wenxiang Cong¹

Academic Editor: Ming Jiang

Received21 Jul 2006

Revised30 Aug 2006

Accepted05 Sept 2006

Published04 Dec 2006

Abstract

We describe the system design of the first bioluminescence tomography (BLT) system for parallel acquisition of multiple bioluminescent views around a mouse in a number of spectral channels simultaneously. The primary component of this BLT system is a novel mirror module and a unique mouse holder. The mirror module consists of a mounting plate and four mirrors with stages. These mirror stages are right triangular blocks symmetrically arranged and attached to the mounting plate such that the hypotenuse surfaces of the triangular blocks all make 45∘ to the plate surface. The cylindrical/polygonal mouse holder has semitransparent rainbow bands on its side surface for the acquisition of spectrally resolved data. Numerical studies and experiments are performed to demonstrate the feasibility of this system. It is shown that bioluminescent signals collected using our system can produce a similar BLT reconstruction quality while reducing the data acquisition time, as compared to the sequential data acquisition mode.

References

B. W. Rice, M. D. Cable, and M. B. Nelson, “In vivo imaging of light-emitting probes,” Journal of Biomedical Optics, vol. 6, no. 4, pp. 432–440, 2001.
View at: Publisher Site | Google Scholar
C. H. Contag and M. H. Bachmann, “Advances in in vivo bioluminescence imaging of gene expression,” Annual Review of Biomedical Engineering, vol. 4, pp. 235–260, 2002.
View at: Publisher Site | Google Scholar
V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nature Biotechnology, vol. 23, no. 3, pp. 313–320, 2005.
View at: Publisher Site | Google Scholar
G. Wang, E. A. Hoffman, and G. McLennan, “Systems and methods for bioluminescent CT reconstruction,” Patent disclosure filled, July 2002; US provisional patent application filled, March 2003; US patent application filed, March 2004.
View at: Google Scholar
G. Wang et al., “Multi-spectral bioluminescence tomography methods and systems,” Patent disclosure filed with University of Iowa Research Foundation, April 2004; provisional patent filed.
View at: Google Scholar
G. Wang, D. Kumar, H. Shen, X. Qian, and W. Cong, “The Optical molecular tomography systems and methods for simultaneous acquisition of multi-view and multi-spectral data,” Patent disclosure filed with University of Iowa Research Foundation, May 2006.
View at: Google Scholar
G. Wang, E. A. Hoffman, G. McLennan et al., “Development of the first bioluminescent CT scanner,” Radiology, vol. 229(P), p. 566, 2003.
View at: Google Scholar
G. Wang, Y. Li, and M. Jiang, “Uniqueness theorems in bioluminescence tomography,” Medical Physics, vol. 31, no. 8, pp. 2289–2299, 2004.
View at: Publisher Site | Google Scholar
M. Jiang and G. Wang, “Image reconstruction for bioluminescence tomography,” in Developments in X-Ray Tomography IV, vol. 5535 of Proceedings of SPIE, pp. 335–351, Denver, Colo, USA, August 2004.
View at: Publisher Site | Google Scholar
W. Cong, D. Kumar, Y. Liu, A. Cong, and G. Wang, “A practical method to determine the light source distribution in bioluminescent imaging,” in Developments in X-Ray Tomography IV, vol. 5535 of Proceedings of SPIE, pp. 679–686, Denver, Colo, USA, August 2004.
View at: Publisher Site | Google Scholar
W. Cong, G. Wang, D. Kumar et al., “Practical reconstruction method for bioluminescence tomography,” Optics Express, vol. 13, no. 18, pp. 6756–6771, 2005.
View at: Publisher Site | Google Scholar
W. Cong and G. Wang, “Boundary integral method for bioluminescence tomography,” Journal of Biomedical Optics, vol. 11, no. 2, Article ID 020503, 3 pages, 2006.
View at: Publisher Site | Google Scholar
W. Cong, D. Kumar, L. V. Wang, and G. Wang, “A Born-type approximation method for bioluminescence tomography,” Medical Physics, vol. 33, no. 3, pp. 679–686, 2006.
View at: Publisher Site | Google Scholar
A. Cong and G. Wang, “Multispectral bioluminescence tomography: methodology and simulation,” International Journal of Biomedical Imaging, vol. 2006, Article ID 57614, 7 pages, 2006.
View at: Publisher Site | Google Scholar
X. Gu, Q. Zhang, L. Larcom, and H. Jiang, “Three-dimensional bioluminescence tomography with model-based reconstruction,” Optics Express, vol. 12, no. 17, pp. 3996–4000, 2004.
View at: Publisher Site | Google Scholar
C. Kuo, O. Coquoz, T. Troy, D. Zwarg, and B. Rice, “Bioluminescent tomography for in vivo localization and quantification of luminescent sources from a multiple-view imaging system,” Molecular Imaging, vol. 4, p. 370, 2005.
View at: Google Scholar
G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study,” Physics in Medicine and Biology, vol. 50, no. 17, pp. 4225–4241, 2005.
View at: Publisher Site | Google Scholar
A. J. Chaudhari, F. Darvas, J. R. Bading et al., “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Physics in Medicine and Biology, vol. 50, no. 23, pp. 5421–5441, 2005.
View at: Publisher Site | Google Scholar
N. V. Slavine, M. A. Lewis, E. Richer, and P. P. Antich, “Iterative reconstruction method for light emitting sources based on the diffusion equation,” Medical Physics, vol. 33, no. 1, pp. 61–68, 2006.
View at: Publisher Site | Google Scholar
H. Dehghani, S. C. Davis, S. Jiang, B. W. Pogue, K. D. Paulsen, and M. S. Patterson, “Spectrally resolved bioluminescence optical tomography,” Optics Letters, vol. 31, no. 3, pp. 365–367, 2006.
View at: Publisher Site | Google Scholar
G. Wang, H. Shen, W. Cong, S. Zhao, and G. W. Wei, “Temperature-modulated bioluminescence tomography,” Optics Express, vol. 14, no. 17, pp. 7852–7871, 2006.
View at: Publisher Site | Google Scholar
H. Zhao, T. C. Doyle, O. Coquoz, F. Kalish, B. W. Rice, and C. H. Contag, “Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo,” Journal of Biomedical Optics, vol. 10, no. 4, Article ID 041210, 9 pages, 2005.
View at: Publisher Site | Google Scholar
A. Ishimaru, Wave Propagation and Scattering in Random Media, Oxford University Press, Oxford, UK, 1997.
F. Natterer and F. Wüng, Mathematical Methods in Image Reconstruction, Society for Industrial and Applied Mathematics, Philadelphia, Pa, USA, 2001.
http://omlc.ogi.edu/spectra/hemoglobin/index.html.
V. Tuchin, Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis, SPIE-International Society for Optical Engine, Bellingham, Wash, USA, 2000.
W. F. Cheong, S. A. Prahl, and A. J. Welch, “A review of the optical properties of biological tissues,” IEEE Journal of Quantum Electronics, vol. 26, no. 12, pp. 2166–2185, 1990.
View at: Publisher Site | Google Scholar

Copyright

Copyright © 2006 Ge Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PDF Download Citation Order printed copies

Views

408

Downloads

1349

Citations