A Parallel Reconstruction Scheme in Fluorescence Tomography Based on Contrast of Independent Inversed  Absorption Properties

Song, Xiaolei; Yi, Ji; Bai, Jing

doi:https://doi.org/10.1155/IJBI/2006/70839

International Journal of Biomedical Imaging

On this page

Abstract References Copyright Related Articles

Open Access

Volume 2006 | Article ID 070839 | https://doi.org/10.1155/IJBI/2006/70839

A Parallel Reconstruction Scheme in Fluorescence Tomography Based on Contrast of Independent Inversed Absorption Properties

Xiaolei Song,¹Ji Yi,¹and Jing Bai¹

Academic Editor: Ming Jiang

Received21 Feb 2006

Revised05 Jun 2006

Accepted13 Aug 2006

Published14 Dec 2006

Abstract

Based on an independent forward model in fluorescent tomography, a parallel reconstructed scheme for inhomogeneous mediums with unknown absorption property is proposed in this paper. The method considers the two diffusion equations as separately describing the propagation of excited light in tissues with and without fluorescent probes inside. Then the concentration of fluorophores is obtained directly through the difference between two estimations of absorption coefficient which can be parallel inversed. In this way, the multiparameter estimation problem in fluorescent tomography is transformed into two independent single-coefficient determined schemes of diffusion optical tomography (DOT). Any algorithms proved to be efficient and effective in DOT can be directly applied here. In this study the absorption property is estimated from the independent diffusion equations by a gradient-based optimization method with finite element method (FEM) solving the forward model. Simulation results of three representative occasions show that the reconstructed method can well estimate fluorescent property and tissue absorption distribution.

References

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nature Biotechnology, vol. 23, no. 3, pp. 313–320, 2005.
View at: Publisher Site | Google Scholar
V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” European Radiology, vol. 13, no. 1, pp. 195–208, 2003.
View at: Google Scholar
H. Jiang, “Frequency-domain fluorescent diffusion tomography: a finite-element-based algorithm and simulations,” Applied Optics, vol. 37, no. 22, pp. 5337–5343, 1998.
View at: Google Scholar
D. Y. Paithankar, A. U. Chen, B. W. Pogue, M. S. Patterson, and E. M. Sevick-Muraca, “Imaging of fluorescent yield and lifetime from multiply scattered light reemitted from random media,” Applied Optics, vol. 36, no. 10, pp. 2260–2272, 1997.
View at: Google Scholar
A. B. Milstein, S. Oh, K. J. Webb et al., “Fluorescence optical diffusion tomography,” Applied Optics, vol. 42, no. 16, pp. 3081–3094, 2003.
View at: Google Scholar
M. A. O'Leary, D. A. Boas, X. D. Li, B. Chance, and A. G. Yodh, “Fluorescence lifetime imaging in turbid media,” Optics Letters, vol. 21, no. 2, pp. 158–160, 1996.
View at: Google Scholar
V. Ntziachristos and R. Weissleder, “Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation,” Optics Letters, vol. 26, no. 12, pp. 893–895, 2001.
View at: Google Scholar
E. L. Hull, M. G. Nichols, and T. H. Foster, “Localization of luminescent inhomogeneities in turbid media with spatially resolved measurements of cw diffuse luminescence emittance,” Applied Optics, vol. 37, no. 13, pp. 2755–2765, 1998.
View at: Google Scholar
R. B. Schulz, J. Peter, W. Semmler, and W. Bangerth, “Independent modeling of fluorescence excitation and emission with the finite element method,” in Proceedings of OSA Biomedical Topical Meetings, Miami, Fla, USA, April 2004.
View at: Google Scholar
M. J. Eppstein, F. Fedele, J. Laible, C. Zhang, A. Godavarty, and E. M. Sevick-Muraca, “A comparison of exact and approximate adjoint sensitivities in fluorescence tomography,” IEEE Transactions on Medical Imaging, vol. 22, no. 10, pp. 1215–1223, 2003.
View at: Publisher Site | Google Scholar
B. J. Tromberg, O. Coquoz, J. B. Fishkin et al., “Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration,” Philosophical Transactions of the Royal Society of London Series B Biological Sciences, vol. 352, no. 1354, pp. 661–668, 1997.
View at: Publisher Site | Google Scholar
S. R. Arridge and M. Schweiger, “A gradient-based optimisation scheme for optical tomography,” Optics Express, vol. 2, no. 6, pp. 213–226, 1998.
View at: Google Scholar
J. Zhou, J. Bai, and P. He, “Spatial location weighted optimization scheme for DC optical tomography,” Optics Express, vol. 11, no. 2, pp. 141–150, 2003.
View at: Google Scholar
S. R. Arridge and M. Schweiger, “Photon-measurement density functions. Part 2: finite-element-method calculations,” Applied Optics, vol. 34, no. 34, pp. 8026–8037, 1995.
View at: Google Scholar
M. Schweiger, S. R. Arridge, M. Hiraoka, and D. T. Delpy, “The finite element method for the propagation of light in scattering media: boundary and source conditions,” Medical Physics, vol. 22, no. 11, pp. 1779–1792, 1995.
View at: Publisher Site | Google Scholar
A. Joshi, W. Bangerth, and E. M. Sevick-Muraca, “Adaptive finite element based tomography for fluorescence optical imaging in tissue,” Optics Express, vol. 12, no. 22, pp. 5402–5417, 2004.
View at: Publisher Site | Google Scholar
E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, “A submillimeter resolution fluorescence molecular imaging system for small animal imaging,” Medical Physics, vol. 30, no. 5, pp. 901–911, 2003.
View at: Publisher Site | Google Scholar
J. K. Jaiswal, H. Mattoussi, J. M. Mauro, and S. M. Simon, “Long-term multiple color imaging of live cells using quantum dot bioconjugates,” Nature Biotechnology, vol. 21, no. 1, pp. 47–51, 2003.
View at: Publisher Site | Google Scholar

Copyright

Copyright © 2006 Xiaolei Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PDF Download Citation Order printed copies

Views

471

Downloads

856

Citations