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International Journal of Biomedical Imaging
Volume 2007, Article ID 15635, 12 pages
Research Article

A Feature-Selective Independent Component Analysis Method for Functional MRI

1Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
2The MIND Institute, University of New Mexico, Albuquerque, NM 87106, USA
3Department of ECE, University of New Mexico, Albuquerque, NM 87106, USA
4Department of Psychiatry, Yale University, New Haven, CT 06520, USA

Received 6 May 2007; Revised 9 August 2007; Accepted 5 October 2007

Academic Editor: Yue Wang

Copyright © 2007 Yi-Ou Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this work, we propose a simple and effective scheme to incorporate prior knowledge about the sources of interest (SOIs) in independent component analysis (ICA) and apply the method to estimate brain activations from functional magnetic resonance imaging (fMRI) data. We name the proposed method as feature-selective ICA since it incorporates the features in the sample space of the independent components during ICA estimation. The feature-selective scheme is achieved through a filtering operation in the source sample space followed by a projection onto the demixing vector space by a least squares projection in an iterative ICA process. We perform ICA estimation of artificial activations superimposed into a resting state fMRI dataset to show that the feature-selective scheme improves the detection of injected activation from the independent component estimated by ICA. We also compare the task-related sources estimated from true fMRI data by a feature-selective ICA algorithm versus an ICA algorithm and show evidence that the feature-selective scheme helps improve the estimation of the sources in both spatial activation patterns and the time courses.