The Advantage of PET and CT Integration in Examination of Lung Tumors

Lu, Guangming; Wang, Zhongqiu; Zhu, Hong; Chang, Linfeng; Chen, Yingxin; Wu, Jiang; Zhao, Yane

doi:https://doi.org/10.1155/2007/17131

International Journal of Biomedical Imaging

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Recent Advances in Molecular Imaging

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Research Article | Open Access

Volume 2007 | Article ID 017131 | https://doi.org/10.1155/2007/17131

The Advantage of PET and CT Integration in Examination of Lung Tumors

Guangming Lu,¹Zhongqiu Wang,¹Hong Zhu,¹Linfeng Chang,¹Yingxin Chen,¹Jiang Wu,¹and Yane Zhao¹

Academic Editor: Jing Bai

Received25 Jan 2007

Revised30 Jun 2007

Accepted17 Jul 2007

Published01 Nov 2007

Abstract

Purpose. To evaluate the diagnosis value of integrated positron emission tomography and computed tomography (PET/CT) with lung masses, this study emphasized the correlation between tumor size and maximum standardized uptake value (SUVmax) in selected regions of interest (ROI) of lung masses. Material and Methods. A retrospective analysis was performed on 85 patients with solid pulmonary lesions, all verified by pathology. The morphology, edge (speculated margins and lobule), size, density of pulmonary masses, and on-chest CT images were reviewed. The SUVmax in ROI of pulmonary masses was calculated. Results. Among the 85 patients with lung masses, 59 patients presented with pulmonary malignant neoplasm and 26 patients with benign lesions. The sensitivity, specificity, and accuracy were 89.8%, 61.5%, 81.2%, respectively, for PET measurement only, 88.1%, 65.4%, 81.2% for CT only, and 96.6%, 80.8%, 91.8% for PET/CT. The size of pulmonary malignant neoplasm in the 59 patients was apparently correlated with the ROI's SUVmax (r=0.617, P<.001). However, the size of pulmonary benign mass in the 26 patients was not correlated with the SUVmax. Conclusion. PET/CT is of greater value in characterization of lung masses than PET and CT performed separately. The examination of lung tumor can be further specified by the correlation between the size of pulmonary malignant neoplasm and the ROI's SUVmax.

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Copyright

Copyright © 2007 Guangming Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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