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International Journal of Biomedical Imaging
Volume 2008 (2008), Article ID 591618, 6 pages
http://dx.doi.org/10.1155/2008/591618
Research Article

In Vitro Assessment of Optical Properties of Blood by Applying the Extended Huygens-Fresnel Principle to Time-Domain Optical Coherence Tomography Signal at 1300 nm

National Research Council of Canada, Institute for Biodiagnostics, 435 Ellice Avenue, Winnipeg, MB, Canada R3B 1Y6

Received 7 March 2008; Accepted 12 June 2008

Academic Editor: Min Gu

Copyright © 2008 Dan P. Popescu and Michael G. Sowa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A direct method for the measurement of the optical attenuation coefficient and the scattering anisotropy parameter based on applying the extended Huygens-Fresnel principle to optical coherence tomography images of blood is demonstrated. The images are acquired with a low-power probing beam at the wavelength of 1300 nm. Values of 12.15  m m 1 and 0.95 are found for the total attenuation coefficient and the scattering anisotropy factor, respectively. Also, as a preliminary step, the optical refraction index is determined with a precision of two decimal numbers directly from optical coherence images. The total attenuation coefficient and the scattering anisotropy factor are determined with precisions within experimental error margins of 5% and 2%, respectively. Readable OCT signal is obtained for a maximum propagation of light into blood of 0.25 mm. At the maximum probed depth, the measured signal is almost 1 0 3 smaller than its initial intensity when entering the sample.