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International Journal of Biomedical Imaging
Volume 2009, Article ID 231539, 8 pages
Research Article

Imaging Multidimensional Therapeutically Relevant Circadian Relationships

1Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USA
2School of Medicine, University of South Carolina, SC 29209, USA
3School of Public Health, University of South Carolina, SC 29209, USA
4College of Engineering and Computing, University of South Carolina, SC 29209, USA
5Center for Colon Cancer Research, University of South Carolina, SC 29209, USA

Received 4 February 2009; Accepted 20 May 2009

Academic Editor: Sun Yoo

Copyright © 2009 Jamil Singletary et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Circadian clocks gate cellular proliferation and, thereby, therapeutically target availability within proliferative pathways. This temporal coordination occurs within both cancerous and noncancerous proliferating tissues. The timing within the circadian cycle of the administration of drugs targeting proliferative pathways necessarily impacts the amount of damage done to proliferating tissues and cancers. Concurrently measuring target levels and associated key pathway components in normal and malignant tissues around the circadian clock provides a path toward a fuller understanding of the temporal relationships among the physiologic processes governing the therapeutic index of antiproliferative anticancer therapies. The temporal ordering among these relationships, paramount to determining causation, is less well understood using two- or three-dimensional representations. We have created multidimensional multimedia depictions of the temporal unfolding of putatively causative and the resultant therapeutic effects of a drug that specifically targets these ordered processes at specific times of the day. The systems and methods used to create these depictions are provided, as well as three example supplementary movies.