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International Journal of Biomedical Imaging
Volume 2009, Article ID 231539, 8 pages
http://dx.doi.org/10.1155/2009/231539
Research Article

Imaging Multidimensional Therapeutically Relevant Circadian Relationships

1Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USA
2School of Medicine, University of South Carolina, SC 29209, USA
3School of Public Health, University of South Carolina, SC 29209, USA
4College of Engineering and Computing, University of South Carolina, SC 29209, USA
5Center for Colon Cancer Research, University of South Carolina, SC 29209, USA

Received 4 February 2009; Accepted 20 May 2009

Academic Editor: Sun Yoo

Copyright © 2009 Jamil Singletary et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1 shows the circadian variation in tumor size and thymidylate synthase in tumor and normal tissues.

Supplementary Table 2 shows the circadian-dependent 5-FU effects on host toxicity, anti-tumor efficacy and toxic-therapeutic index.

Supplementary Table 3 shows the circadian variation in tumor histopathology.

Supplementary Movie 1 depicts the relationship of tumor size and tumor TS message, protein, enzyme activity, and tumor nuclear BMAL1 within the circadian cycle.

Supplementary Movie 2 shows the relationship of tumor size to tumor mitotic index (vertical axis), tumor cell VEGF (horizontal axis) and tumor WEE-1 (oblique axis) over the circadian cycle.

Supplementary Movie 3 depicts the relationship of 5-FU toxic-therapeutic index (TI) to the amount of drug target (e.g. TSA) in the gut epithelium cells, nucleated bone marrow cells, and tumor cells.

  1. Supplementary Tables
  2. Supplementary Movie 1
  3. Supplementary Movie 2
  4. Supplementary Movie 3