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International Journal of Biomedical Imaging
Volume 2009 (2009), Article ID 847537, 7 pages
Research Article

Varying Collimation for Dark-Field Extraction

1SBES Division/ICTAS Center for Biomedical Imaging, VT-WFU School of Biomedical Engineering, Virginia Tech, Blacksburg, VA 24061, USA
2Toshiba Medical Research Institute USA, Vernon Hills, IL 60061, USA

Received 10 May 2009; Accepted 12 November 2009

Academic Editor: Yibin Zheng

Copyright © 2009 Ge Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although x-ray imaging is widely used in biomedical applications, biological soft tissues have small density changes, leading to low contrast resolution for attenuation-based x-ray imaging. Over the past years, x-ray small-angle scattering was studied as a new contrast mechanism to enhance subtle structural variation within the soft tissue. In this paper, we present a detection method to extract this type of x-ray scattering data, which are also referred to as dark-field signals. The key idea is to acquire an x-ray projection multiple times with varying collimation before an x-ray detector array. The projection data acquired with a collimator of a sufficiently high collimation aspect ratio contain mainly the primary beam with little scattering, while the data acquired with an appropriately reduced collimation aspect ratio include both the primary beam and small-angle scattering signals. Then, analysis of these corresponding datasets will produce desirable dark-field signals; for example, via digitally subtraction. In the numerical experiments, the feasibility of our dark-field detection technology is demonstrated in Monte Carlo simulation. The results show that the acquired dark field signals can clearly reveal the structural information of tissues in terms of Rayleigh scattering characteristics.