Hybrid ICA-Seed-Based Methods for fMRI Functional Connectivity Assessment: A Feasibility Study

Table 5

Experiment 4: mean correlations of subject-specific FC spatial maps with (1) the task-related GLM map for the same subject (“Task-Related” column) and (2) the group IC of interest (“Group IC” column). Results of a paired 𝑡-test comparison of the mean correlations are shown in the rightmost columns. These results were based on a group ICA that produced 5 components.

Method of Generating Maps	Group ICA Source	Mean Correlation With Subject-Specific Map (95% Confidence Interval)		Same = Seed Null Hypothesis Test
		Task-Related	Group ICA	𝑡	df	𝑃
Single-voxel seed (SV)	PICA	0.57 (0.45–0.68)	0.47 (0.43–0.51)	2.0	13	.06
9-voxel ROI seed (FV)	PICA	0.81 (0.73–0.86)	0.53 (0.49–0.57)	5.8	13	<.001
40-voxel ROI seed (MV)	PICA	0.83 (0.77–0.87)	0.56 (0.52–0.60)	7.0	13	<.001
Dual regression, 1 spatial map (DRS)	PICA	0.77 (0.67–0.83)	0.59 (0.57–0.61)	3.7	13	.002
Dual regression, all spatial maps (DRA)	PICA	0.57 (0.46–0.65)	0.62 (0.59–0.64)	−1.2	13	.24