Hybrid ICA-Seed-Based Methods for fMRI Functional Connectivity Assessment: A Feasibility Study

Table 7

Experiment 5: mean correlations of subject-specific FC spatial maps with (1) the task-related GLM map for the same subject (“Task-Related” column) and (2) the group IC of interest (“Group IC” column). Results of a paired 𝑡-test comparison of the mean correlations are shown in the rightmost columns. These results were based on a group ICA that produced 30 components.

Method of Generating Maps	Group ICA Source	Mean Correlation WithSubject-Specific Map(95% Confidence Interval)		Same = SeedNull HypothesisTest
		Task-Related	Group ICA	𝑡	df	𝑃
Single-voxel seed (SV)	PICA	0.82 (0.75–0.88)	0.48 (0.44–0.52)	7.5	13	<.001
9-voxel ROI seed (FV)	PICA	0.84 (0.77–0.89)	0.49 (0.45–0.53)	7.5	13	<.001
40-voxel ROI seed (MV)	PICA	0.85 (0.79–0.89)	0.50 (0.45–0.54)	8.3	13	<.001
Dual regression, 1 spatial map (DRS)	PICA	0.88 (0.84–0.92)	0.51 (0.48–0.54)	9.8	13	<.001
Dual regression, all spatial maps (DRA)	PICA	0.43 (0.36–0.49)	0.52 (0.48–0.55)	−4.0	13	.002