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International Journal of Biomedical Imaging
Volume 2012 (2012), Article ID 247161, 8 pages
http://dx.doi.org/10.1155/2012/247161
Research Article

Metabolite Mapping with Extended Brain Coverage Using a Fast Multisection MRSI Pulse Sequence and a Multichannel Coil

1Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
2Department of Psychiatry, Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, No. #74, New York, NY 10032, USA

Received 28 July 2011; Accepted 16 November 2011

Academic Editor: Eric C. Bourekas

Copyright © 2012 Zhengchao Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Multisection magnetic resonance spectroscopic imaging is a widely used pulse sequence that has distinct advantages over other spectroscopic imaging sequences, such as dynamic shimming, large region-of-interest coverage within slices, and rapid data acquisition. It has limitations, however, in the number of slices that can be acquired in realistic scan times and information loss from spacing between slices. In this paper, we synergize the multi-section spectroscopic imaging pulse sequence with multichannel coil technology to overcome these limitations. These combined techniques now permit elimination of the gaps between slices and acquisition of a larger number of slices to realize the whole brain metabolite mapping without incurring the penalties of longer repetition times (and therefore longer acquisition times) or lower signal-to-noise ratios.