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International Journal of Biomedical Imaging
Volume 2012, Article ID 509783, 11 pages
http://dx.doi.org/10.1155/2012/509783
Research Article

Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System

Department of Bioengineering, University of Washington, Seattle, WA 98195, USA

Received 4 January 2012; Accepted 13 April 2012

Academic Editor: Richard H. Bayford

Copyright © 2012 Roberto Reif et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained with a spectral domain optical coherence tomography system. A technique for determining three measureable parameters (the fractal dimension, the vessel length fraction, and the vessel area density) is proposed and validated. Finally, the repeatability for acquiring OMAG images is determined, and a new method for analyzing small areas from these images is proposed.