Classification of Alzheimer’s and MCI Patients from Semantically Parcelled PET Images: A Comparison between AV45 and FDG-PET

Table 3

Classification performance in multiregion approaches (SVM, PCA, RBF, and RF), evaluating accuracy (ACC), sensitivity (SEN), specificity (SPE), and area under the curve (AUC). (a) AD versus NC; (b) AD versus EMCI; (c) AD versus LMCI; (d) EMCI versus LMCI.

(a)

Method	Timepoints	ACC	SEN	SPE	AUC
SVM	1st visit	81.7	83.5	72.8	0.843
	1st + 2nd visit	81.0	83.2	70.8	0.839
PCA	1st visit	85.7	84.3	79.2	0.876
	1st + 2nd visit	87.1	86.1	80.6	0.884
RBF	1st visit	88.2	86.4	85.2	0.894
	1st + 2nd visit	89.3	88.8	85.9	0.900
RF	1st visit	88.2	89.5	86.8	0.901
	1st + 2nd visit	89.7	89.1	87.0	0.903

(b)

Method	Timepoints	ACC	SEN	SPE	AUC
SVM	1st visit	70.0	76.3	59.8	0.745
	1st + 2nd visit	74.0	81.4	62.3	0.767
PCA	1st visit	74.5	77.2	65.9	0.772
	1st + 2nd visit	74.0	79.7	66.0	0.778
RBF	1st visit	76.5	79.1	67.4	0.791
	1st + 2nd visit	81.7	86.5	70.3	0.866
RF	1st visit	82.4	85.2	76.9	0.874
	1st + 2nd visit	82.4	85.3	76.9	0.876

(c)

Method	Timepoints	ACC	SEN	SPE	AUC
SVM	1st visit	60.0	66.5	69.2	0.675
	1st + 2nd visit	63.2	70.7	51.5	0.673
PCA	1st visit	66.1	70.0	64.8	0.691
	1st + 2nd visit	57.1	55.6	60.0	0.625
RBF	1st visit	66.1	69.3	71.4	0.705
	1st + 2nd visit	70.1	74.2	65.7	0.754
RF	1st visit	73.2	75.6	77.2	0.788
	1st + 2nd visit	75.0	74.1	76.1	0.796

(d)

Method	Timepoints	ACC	SEN	SPE	AUC
SVM	1st visit	65.0	64.6	67.2	0.698
	1st + 2nd visit	70.0	68.3	73.4	0.756
PCA	1st visit	53.0	55.7	59.1	0.578
	1st + 2nd visit	53.0	55.6	60.2	0.577
RBF	1st visit	62.3	64.3	66.5	0.684
	1st + 2nd visit	67.6	70.1	70.7	0.788
RF	1st visit	65.2	69.0	63.2	0.724
	1st + 2nd visit	65.2	69.2	63.9	0.727