Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration
Figure 5
Histological photomicrographs: (a) Control group: 1 week. Bone defect filled by fibrotic tissue (white star); inflammatory infiltrate (white arrow). Hematoxylin-eosin staining (HE), scale bar (500 μm); (b) Treated group: 1 week. Bone defect filled by newly formed bone, osteoids (om), medullary spaces with mesenchymal cells (ms), and several blood vessels (v); mature bone (B); BC-HA membrane (black star); inflammatory infiltrate (I) (HE), scale bar (500 μm); (c) Control group: 4 weeks. New formed bone tissue is observed with several osteocytes (black arrows), blood vessels (arrow heads), and medullary spaces (stars); bone defect is not filled completely (white star) (HE), scale bar (100 μm); (d) Treated group: 4 weeks. BC-HA membrane (star), periosteum (P), osteoblasts (white arrow), osteocytes (arrow heads), and bone matrix (blue arrow) (HE), scale bar (100 μm); (e) Control group: 16 weeks. Mature bone (HE), scale bar (200 μm). (f) Treated group: 16 weeks. BC-HA membrane (star); bone defect completely repaired by mature bone, osteocytes (black arrows), and blood vessels (arrow head) (HE), scale bar (200 μm).
