Research Article

Effect of Age and Diabetes on the Response of Mesenchymal Progenitor Cells to Fibrin Matrices

Figure 2

Effects of fibrin surfaces on healthy and diabetic rat MSC. MSC isolated from young and diabetic rats were grown on fibrin gels for 7 days, and then 1000 cells were seeded into the CFU assays under osteogenic conditions. ALP-positive (grey) and total colony numbers (black) were calculated for normal rat MSC (a) as well as the mean size of the colonies (b). CFU numbers for MSC from were also calculated (c) as well as the mean colony size (d). *Denotes a statistically significant difference from the other groups.
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(a) Rat MSC
378034.fig.002b
(b) Average colony area
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(c) Diabetic rat MSC
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(d) Average colony area