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International Journal of Biomaterials
Volume 2012, Article ID 390947, 11 pages
Research Article

Synthesis of Block Copolymers of Varying Architecture Through Suppression of Transesterification during Coordinated Anionic Ring Opening Polymerization

1School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue 50, Singapore 639798
2Laboratory of Polymer Science and Advanced Organic Materials, LEMP/MAO, Institut Charles Gerhardt de Montpellier, Université Montpellier 2, Place Eugene Bataillon, 34095 Montpellier, France

Received 6 March 2012; Revised 27 April 2012; Accepted 27 April 2012

Academic Editor: Esmaiel Jabbari

Copyright © 2012 Vitali T. Lipik and Marc J. M. Abadie. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Well-defined di- and triblock copolymers consisting of ε-caprolactone (CL), L-lactide (LA), and trimethylene carbonate (TMC) were synthesized via “PLA first route” in coordinated anionic ring opening polymerization/copolymerization (CAROP) with tin (II) octoate as catalyst. The desired block structure was preserved by use of protective additive α-methylstyrene by preventing the transesterification side-reactions. MALDI-TOF analysis revealed that the protection mechanism is associated with α-methylstyrene and tin (II) octoate complexation. Additionally, it was shown that use of α-methylstyrene in ring opening polymerization allowed the formation of polyesters with high molar mass.