Perfusion Flow Enhances Osteogenic Gene Expression and the Infiltration of Osteoblasts and Endothelial Cells into Three-Dimensional Calcium Phosphate Scaffolds

Table 2

Changes in mRNA levels with perfusion flow (osteoblast cultures) at 1 and 2 days.

Gene	7-day fold change	𝑃 value	14-day fold change	𝑃 value
VEGF	↓48%	0.02	—	0.32
OPN	↓10%	0.03	—	0.14
COX-2	↑67%	0.02	—	0.25
HIF-l𝛼	—	—	↓45%	0.02