Systemic siRNA Delivery via Peptide-Tagged Polymeric Nanoparticles, Targeting PLK1 Gene in a Mouse Xenograft Model of Colorectal Cancer
Figure 7
Serum analysis was performed as a safety test for comparing the (a) CRP and (b) ALT, AST levels among different treatment groups. The results indicate no significant difference between the treatment group (CS-PEG-CP15) containing siRNA against PLK1 gene with mock transfections and untreated controls. This concludes that the treatment formulation had no deleterious effect in terms of toxicity and immunological reactions on the animals. The graph shows a representative result of in each group, mean ± SE, with no statistical significance according to Tuckey’s post hoc analysis, when compared with other groups.
