A Crosslinked HA-Based Hydrogel Ameliorates Dry Eye Symptoms in Dogs
Table 1
Scores of ocular health before and after 2 weeks of treatment (twice daily) of the xCMHA-S gel in a clinical study on dogs.
Case
Breed
Age (yrs)/Gender
STT before (mm/min)
STT after (mm/min)
Hyperaemia Before
Hyperaemia After
Irritation Before
Irritation After
Discharge Before
Discharge After
1
CKCS
8/Fn
2/4
3/3
2/2
1/1
2/2
0/0
1/1
0/0
2
Bulldog
6/Fn
10/9
6/2
2/2
0/0
1/1
0/0
2/2
0/0
3
Crossbred
10/Fn
8/4
9/6
2/1
1/0
2/0
0/0
2/1
0/0
4
St. Poodle
11/Fn
7/4
6/4
2/2
0/0
2/1
0/0
1/1
0/0
5
CKCS
6/Fn
2/2
3/3
1/1
0/0
1/1
0/0
0/0
0/0
6
CKCS
8/Fn
3/3
3/4
2/2
0/0
2/2
0/0
1/1
0/0
7
Shih Tzu
12/Fn
2/1
3/1
2/2
0/0
2/2
0/0
2/2
1/1
8
Shih Tzu
8/Fe
0/1
2/2
2/2
1/1
2/2
0/0
1/1
0/0
9
Bassett
7/Mn
4/9
2/8
2/2
1/1
2/2
0/0
0/0
0/0
10
WHWT
12/Fn
2/1
4/3
2/2
1/1
2/2
1/1
1/1
0/1
11
Lhasa Apso
11/Fe
3/7
2/6
1/1
0/0
1/1
0/0
0/0
0/0
12
ECS
10/Mn
3/2
3/2
2/2
0/0
1/1
0/0
1/1
0/0
13
Eng Setter
7/Mn
8/7
7/7
1/1
0/0
1/1
0/0
0/0
0/0
14
Min Schn
8/Fn
9/8
8/7
1/1
0/0
2/2
0/0
0/0
0/0
15
ECS
9/Fe
3/5
2/5
1/1
0/0
1/1
0/0
0/0
0/0
16
ECS
8/Fn
3/7
2/6
2/2
0/1
2/2
0/0
1/1
0/0
17
WHWT
13/Fn
0/1
2/2
2/2
0/0
2/2
0/0
2/2
1/1
18
WHWT
5/Fe
0/0
1/2
1/1
0/0
1/1
0/0
1/1
0/0
19
Rottweiler
8/Me
3/8
4/9
2/2
1/1
2/2
1/1
0/0
0/0
20
Shih Tzu
7/Fn
4/7
5/8
2/1
1/1
1/1
0/0
0/0
0/0
21
Weimaraner
8/Mn
9/9
8/12
2/2
1/1
2/2
0/0
0/0
0/0
22
ECS
10/Fn
4/5
4/5
2/2
0/0
2/2
1/1
0/0
0/0
23
ECS
12/Fn
5/5
3/6
1/1
0/0
1/1
0/0
0/0
0/0
24
Shih Tzu
7/Me
5/6
6/6
2/2
0/0
1/1
1/1
1/1
0/0
25
Shih Tzu
9/Fn
4/4
5/4
2/2
0/0
2/2
1/1
0/0
0/0
Mean SD
/
/
/
/
/
/
/
/
P value
1.00/0.67
/
/
/
All scores given are for right eye/left eye and indicate normal , mildly impaired , or severely impaired . P values indicate comparison between scores before and after treatment. In breed: CKCS: Cavalier King Charles Spaniel; St.: Standard; WHWT: West Highland White Terrier; ECS: English Cocker Spaniel; Eng: English; Min Schn: Miniature Schnauzer. In Gender: Fn: neutered female; Fe: unaltered female; Mn: neutered male; Me: unaltered male. STT: Schirmer tear test.