Research Article

Determination of Oxidative Stress Related Toxicity on Repeated Dermal Exposure of Hydroxyapatite Nanoparticles in Rats

Table 2

Haematological values of rats when exposed to HANPs (mean ± SD, ).

ParametersControlHANPs
(25 mg/kg)(50 mg/kg)(100 mg/kg)

WBC5.64 ± 2.206.25 ± 1.515.85 ± 1.467.62 ± 2.22
RBC6.09 ± 0.396.35 ± 0.486.14 ± 0.636.02 ± 0.63
Hb15.77 ± 0.8115.95 ± 0.9215.46 ± 0.1014.66 ± 0.91
Hct33.03 ± 1.8234.58 ± 2.8333.31 ± 3.1832.12 ± 3.20
PLT705.0 ± 106.66702.7 ± 54.49690.1 ± 85.74600.9 ± 71.45
MCV54.5 ± 1.3554.5 ± 1.0854.4 ± 1.5153.5 ± 0.71
MCH25.91 ± 0.9225.14 ± 0.7625.3 ± 1.4624.52 ± 1.33
MCHC47.75* ± 1.3946.2 ± 1.5746.55 ± 2.1745.89 ± 2.42

Statistically significant ; HANPs: hydroxyapatite nanoparticles.