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International Journal of Biomaterials
Volume 2014 (2014), Article ID 979636, 9 pages
Research Article

Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose

1Stanford University, Stanford, CA 94305, USA
2Hawaii Natural Energy Institute, University of Hawaii, 1680 East West Road, POST 109, Honolulu, HI 96822, USA
3University of Pennsylvania, Philadelphia, PA 19104, USA

Received 22 February 2014; Revised 28 April 2014; Accepted 6 May 2014; Published 21 May 2014

Academic Editor: Claudio Migliaresi

Copyright © 2014 Evan M. Masutani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The effects of ultraviolet (254 nm) radiation on a hydrated gelatin-glucose matrix were investigated for the development of a physiologically thermostable substrate for potential use in cell scaffold production. Experiments conducted with a differential scanning calorimeter indicate that ultraviolet irradiation of gelatin-glucose hydrogels dramatically increases thermal stability such that no melting is observed at temperatures of at least 90°C. The addition of glucose significantly increases the yield of cross-linked product, suggesting that glucose has a role in cross-link formation. Comparisons of lyophilized samples using scanning electron microscopy show that irradiated materials have visibly different densities.