Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin

Figure 12

In vitro antiviral effect of ivermectin formulated in liposomes (closed circles) on Huh-7 cells infected with DENV 2. The following liposomal formulations were tested: #PC9-Ch1-ive1.0 (a) and #PC9-Br1-ive1.0 (b). For comparison, the infected cells were treated with the empty liposomal formulations (open circles). The phosphatidylcholine concentration (top -axis) is related to empty liposomes while the ivermectin concentration (bottom -axis) is related to ivermectin liposomes. Details on the identification codes and liposomal compositions are included in Table 1. Details on the EC₅₀ values are in Table 3. Data represent the average of 2 determinations ± SD.

(a)

(b)