Table 4: Mechanism of anticancer activity of nanochitosan (composite) in some target cells.

Nanochitosan (composite)Target cell(s)Mechanism of actionTestOutcomeYearRef.

Nano chitosanBreast cancer mice model 4Interference to RNA and immunoenhancementIn vivo Inhibition of angiogenesis and proliferation2010 
2015
[17] 
[211]
Human gastric cancer cellsSustained release mannerIn vitroInhibition of cells proliferation2010 
2005
[17] 
[213]
Ovarian cancer cellsBinding of αvβ3 integrin with tumor cell receptorsIn vivoInhibition of tumor growth2010[216]
HCC cellsDecrease in mitochondrial membrane potential, and fragmentation of DNA, suppression of VEGFR2 gene expressionIn vitroCell death and inhibition of angiogenesis2010 
2007
[17] 
[95]

Paclitaxel-glycol chitosan nano compositeMCF-7sustained release of paclitaxel by EPR effectIn vitroTumor growth inhibition2006[214]

Chitosan-curcumin nano formulationSolid tumorSustained release manner, DNA damage, cell cycle blockage and elevation of ROS levelsIn vitroInhibition of tumor growth2018[219]

Chitosan folate hesperetin nanoparticlesHCT15 cellsPassive targeting through the leaky vasculature of tumor environmentIn vivoCellular apoptosis2018[220]

Peptide-labeled chitosan nanoparticleSolid tumorsTumor targeted delivery for short interfering RNA (siRNA)In vivoInhibition of tumor growth2010 [216]