Research Article

Preclinical Testing of New Hydrogel Materials for Cartilage Repair: Overcoming Fixation Issues in a Large Animal Model

Table 1

Overview of the number of defects per group and fixation method for the 2–4 week study. 12 minipigs with trochlea chondral defects with reinforced hydrogels and fibrin glue fixation were euthanized after 2 weeks, and all other animals were euthanized after 4 weeks.

TrochleaCondyle
ChondralOsteochondralChondralOsteochondral
Reinforcement++++

Fibrin glue4234223
BioGlue®4
Fibrin + cover11
Direct suture3
Press-fit + fibrin glue44