Research Article

Hippocampal Glial Degenerative Potentials of Mefloquine and Artequin in Adult Wistar Rats

Figure 1

(a) Hippocampus section of control rats given distilled water, showing normal pyramidal cell neurons (PRN), astrocytes (AST), oligodendrocytes (OL), and astrocytes’ processes (ASP). (b) Section of hippocampus of rats treated with 0.86/1.07 mg/kg of Artequin, showing few populations of pyramidal shaped neuron (PRN) with less visible astrocytes’ processes (ASP), as well as less impregnated oligodendrocytes (OL). (c) Section of hippocampus of rats treated with 1.71/2.14 mg/kg of Artequin, showing mostly prominent astrocytes’ processes (ASP) with less visible pyramidal neurons (PRN) and glia. (d) Section of hippocampus of rats treated with 3.42/4.28 mg/kg of Artequin, showing less visible neurons and glial astrocytes’ processes (ASP) (Silver stain, Mag. ×400).
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