Hippocampal Glial Degenerative Potentials of Mefloquine and Artequin in Adult Wistar Rats
Figure 2
(a) Section of hippocampus of control rats showing normal pyramidal cell neurons (PRN), astrocytes (AST), astrocytes’ processes (ASP), and oligodendrocytes (OL). (b) Section of hippocampus of rats treated with 1.07 mg/kg of Mefloquine, showing few populations of pyramidal neurons (PRN) in pyramidal layer with increased population of astrocytes (AST) and astrocytes’ processes (ASP). (c) Section of hippocampus of rats treated with 2.14 mg/kg of Mefloquine, showing increased population of astrocytes (AST) with less population of pyramidal neurons (PRN) in the pyramidal cell layer (PCL). (d) Section of hippocampus of rats treated with 4.28 mg/kg of Mefloquine, showing less population of neurons in the pyramidal cell (PCL) layer but with increased population of astrocytes (AST) (Silver stain, Mag. ×400).
